I used to pop Tylenol and Advil like candy. Wake up with a headache? Wash that cereal down with some acetaminophen. Tough workout? Cool down with a Gatorade and some ibuprofen. If your medicine cabinet is stocked with any kind of drug, it's likely some type of over-the-counter headache relief product such as Advil, Aleve, Excedrin or Tylenol – or maybe all of the above. Which drug is safer and better for different kinds of pain? Advil and Aleve are popular over-the-counter painkillers that have more similarities than differences between them. Like superheroes, each pain reliever has its own set of strengths and weaknesses. Tylenol vs Advil Tylenol (also known as Acetaminophen) and Advil (also known as ibuprofen) are high quality medicines that provide the basic relief from fever and pain. The American Geriatric Society recommends acetaminophen, the medicine in TYLENOL®, as an important option for relieving mild-to-moderate musculoskeletal pain. The popular pain reliever ibuprofen isn’t without its side effects. Learn about ibuprofen side effects here, including common ones, such as stomach pain. Find out what puts you at risk for rarer. Ibuprofen, sold under the brand names Advil, Motrin, and Ibuprin, is a medication used to relieve pain, swelling and inflammation. Motrin and Advil can be purchased over-the-counter in 200. TYLENOL® Sinus Congestion & Pain tackles tough sinus pain that can result in a headache, effective relief so you can get back to your day. The last time my pet was in pain, I was ready to call the pet-ambulance and spend all of my savings to make them feel better. As pet parents, we tend to act a little bit too hastily when we worry about our pets being injured, sick, or in pain.